Casual DBP decreased from 792mmHg at baseline to 772mmHg after 6weeks of IMST (P=0.03) but was unchanged with sham training (baseline: 811mmHg, endintervention: 811mmHg; P=0.75) (Figure2). Overall, these results are promising and suggest highresistance IMST may lower ambulatory measures of SBP. Coprimary end points were the percentage change in weight from baseline and a weight reduction of 5% or more. more. Millions of articles available in both PDF and HTML full-text with no restrictions; updated daily. Find latest news from every corner of the globe at Reuters.com, your online source for breaking international news coverage. Classification and diagnosis of diabetes. In a so-called natural experiment, two school districts in Boston maintained masking after mandates had been lifted in others, enabling a unique comparison. Kurhade C, Zou J, Xia H, Liu M, Yang Q, Cutler M, Cooper D, Muik A, Sahin U, Jansen KU, Ren P, Xie X, Swanson KA, Shi PY. P<0.05 vs sham. Children with speech difficulties are having trouble being understood to the point that they withdraw. The remaining 5 training sessions each week were performed unsupervised at home. World J Gastroenterol 2010;16:2075-2079. In this double-blind, placebo-controlled, crossover study, 110 individuals were randomized to receive 1 g acetaminophen 4 daily or matched placebo for 2 weeks followed by a 2-week washout period before crossing over to the alternate treatment. Lastly, 6weeks of IMST was safe, tolerable, and promoted excellent adherence in our midlife/older subjects. (Oct. 1947 - May 2012). Masking may cause communication problems and delays in speech development, may be particularly onerous for children with learning disabilities and makes it difficult to read or communicate emotional expressions, critics have said. Thirtysix participants completed highresistance IMST (75% maximal inspiratory pressure, n=18) or lowresistance sham training (15% maximal inspiratory pressure, n=18). Drug-induced hyperkalemia is the most important cause of increased potassium levels in everyday clinical practice. ONeil PM, Birkenfeld AL, McGowan B, et al. The full text coverage for 59 journal titles (48 APA titles and 11 allied associations) includes all journal articles, letters to the editor and errata. Int J Obes (in press). UK study found long-Covid in 1.4% of patients (and approx 1% of controls without ); the Department of Endocrinology, Hematology, and Gerontology, Graduate School of Medicine, Chiba University and Department of Diabetes, Metabolism, and Endocrinology, Chiba University Hospital, Chiba, Japan (K.Y. Teacher's Reference Center (TRC) provides indexing and abstracting to the most popular teacher and administrator trade journals, periodicals and books. Phase I/II study of COVID-19 RNA vaccine BNT162b1 in adults. Short chain fatty acids are known to mediate antiinflammatory responses,59 so it is possible that the increase in hexanoic acid with IMST may play some role in the observed reduction in inflammation, shown by decreased plasma levels of CRP. Semaglutide also improved physical functioning, as assessed by SF-36 and IWQOL-Lite-CT, a finding that is notable given that overweight and obesity significantly impair health-related quality of life.26 Statistical superiority of semaglutide over placebo was achieved for all end points in the hierarchical testing procedure. Table 1. 11. BioOne is an online aggregation of full text, high impact journals in the biological, ecological and environmental sciences. Information and tools for librarians about site license offerings. Scores on the 36-Item Short-Form Health Survey (SF-36) are norm-based, transformed to a scale on which the 2009 general population of the United States has a mean score of 50 and a standard deviation of 10; higher scores indicate better quality of life. In contrast to IMST, exposure to serum from shamtrained subjects did not induce eNOS activation nor suppress ROS bioactivity. A companion to PapersFirst, ProceedingsFirst indexes every published congress, symposium, conference, exposition, workshop and meeting received by The British Library Document Supply Centre. At the beginning and end of each treatment period, 24-hour ambulatory BPs were measured. The treatment-regimen estimand assessed effects regardless of treatment discontinuation in the intention-to-treat population. Periodical collection for beginning students of military science, history, social science, as well as analysts and risk management professionals. Banks PA, Bollen TL, Dervenis C, et al. Its worth pointing out, however, that masks were not a divisive issue until governments began mandating their use. Body composition (total fat, total lean body mass, and regional [abdominal] visceral fat mass) was measured in the DXA subpopulation as a supportive secondary end point. We enrolled adults (18 years of age or older) with one or more self-reported unsuccessful dietary efforts to lose weight and either a BMI of 30 or greater or a BMI of 27 or greater with one or more treated or untreated weight-related coexisting conditions (i.e., hypertension, dyslipidemia, obstructive sleep apnea, or cardiovascular disease). Information, resources, and support needed to approach rotations - and life as a resident. Public health officials have created a giant long-Covid industrial complex, spending billions on MRIs & blood tests that have yielded zero clinical useful info. The NYS Newspapers database is a segment of the larger Infotrac Custom Newspaper database. One death was reported in each group, with neither considered by the independent external event adjudication committee to be related to receipt of semaglutide or placebo (Table 3). We thank the trial participants and the trial site staff; Lisa von Huth Smith of Novo Nordisk, Denmark, for support with data presentation of participant-reported outcomes and critical review of an earlier draft of the manuscript; and Paul Barlass of Axis, a division of Spirit Medical Communications Group, for medical writing and editorial assistance with an earlier draft of the manuscript (funded by Novo Nordisk). Compilation of 10 databases from OCLC, searchable together or separately. Once-Weekly Semaglutide in Adults with Overweight or Obesity. ); the Department of Endocrinology, Diabetology, and Metabolism, Antwerp University Hospital, University of Antwerp, Antwerp, Belgium (L.F.V.G. Many articles are available via open access. To conduct the study, which ran from early April to early June, scientists at the University of Copenhagen recruited more than 6,000 participants who had tested negative for COVID-19 immediately prior to the experiment. Search authoritative medical information using the EbscoHost MEDLINE interface. This is a system organ class. There were no significant interaction effects for any measure of arterial stiffness or carotid IMT in the whole group or the subgroup that completed followup testing (all interaction effects P>0.05). (%), Polycystic ovarian syndrome no./total no. Diabetes Obes Metab 2017;19:336-347. A large, yearlong trial published in JAMA in 2019, for example, found that a Mediterranean diet reduced anxiety but did not prevent depression in a group of people at high risk. Covers magazine and journal articles about current events and general world history . To gain initial insight into any potential trends for sexspecific effects of the intervention on the main functional outcomes, changes in BP, endothelial function, and arterial stiffness prepost IMST were assessed separately in women and men, though betweengroup comparisons were not conducted because of the small number of subjects in those subgroups. **A coexisting condition was a history of any of the following conditions, as reported at screening: dyslipidemia, hypertension, coronary artery disease, cerebrovascular disease, obstructive sleep apnea, impaired glucose metabolism, reproductive system disorders, liver disease, kidney disease, osteoarthritis, gout, or asthma or chronic obstructive pulmonary disease. The study consisted of a 6week randomized, doubleblind, shamcontrolled, paralleldesign clinical trial. At baseline, the mean body weight was 104.8 kg, the mean BMI was 38.0, and 94.5% of participants had a BMI of 30 or higher. To further describe potential homologous and heterologous protection against emerging SARS-CoV-2 VOCs, a new cohort of participants will be enrolled who are COVID-19 vaccine-nave (ie, BNT162b2-nave) and have not experienced COVID-19. 2020 (https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/209637s003lbl.pdf). Mexico implemented a 1 peso per liter excise tax on sugar-sweetened beverages on January 1, 2014, and a previous study found a 6 percent reduction in purchases of taxed beverages in 2014. Christopher Capozziello for The New York Times, were lower among masked students even in Bostons public schools, But some educators are finding ways to integrate it into lessons. Hill and Others More from the week of September 16, 2021 UC Library does not maintain a subscription to access premium content. UK study found long-Covid in 1.4% of patients (and approx 1% of controls without The study consists of 2 parts: Phase 1: to identify preferred vaccine candidate(s) and dose level(s); Phase 2/3: an expanded cohort and efficacy part. But the majority of students still arent wearing them., Masks Cut Covid Spread in Schools, Study Finds, https://www.nytimes.com/2022/11/10/health/covid-schools-masks.html. Records represent the event and include a listing of presented papers. SF-36 physical functioning scores (with possible norm-based scores ranging from 19.03 to 57.60) improved significantly more with semaglutide than with placebo at week 68 (P<0.001), and both SF-36 physical and mental component summary scores favored semaglutide (Table 2, Table S2, and Fig. Wharton S, Lau DCW, Vallis M, et al. Casual SBP and diastolic BP (DBP) were measured according to American College of Cardiology/American Heart Association guidelines6 by a single trained investigator via brachial auscultation on the subject's nondominant arm after 5minutes of quiet rest. Tax court case law But what we see in the study is that Covid does spread in schools, and it spreads back home, and it spreads to teachers.. Children with language-learning difficulties are having trouble understanding their teachers and their peers, Dr. Doron said. In the current study, we performed a rigorous randomized, doubleblind, shamcontrolled, paralleldesign trial to evaluate the efficacy of highresistance IMST for improving cardiovascular function in midlife/older adults with abovenormal SBP. The average number of training sessions completed by the IMST group was 39.75.2 and by the sham group was 37.44.3, with no difference in the number of training sessions between groups (P=0.17). J Intern Med 2013;273:219-234. ); the Comprehensive Weight Control Center, Division of Endocrinology, Diabetes, and Metabolism, Weill Cornell Medicine, New York (L.J.A. The coprimary end points were the percentage change in body weight from baseline to week 68 and achievement of a reduction in body weight of 5% or more from baseline to week 68. But a Boston parents group, BPS Families for Covid Safety, has already called for reinstating of universal masking in schools, saying that the new study provides evidence that the practice protects against both illness and lost days of learning in a district where vaccination rates are relatively low and families come from communities that have suffered disproportionately during the pandemic. n=15 IMST, n=14 sham. Hearst Television participates in various affiliate marketing programs, which means we may get paid commissions on editorially chosen products purchased through our links to retailer sites. In the IMST subjects who completed followup testing (n=15), the decrease in casual SBP from baseline to endintervention (1352mmHg versus 1263mmHg, P<0.01) was identical to the whole group (n=18). A digital journal for innovative original research and fresh, bold ideas in clinical trial design and clinical decision-making. The protocol (available with the full text of this article at NEJM.org) was approved by an independent ethics committee or institutional review board at each study site. There were no baseline differences between groups in any measure of arterial stiffness, including CFPWV, carotid artery compliance, and beta stiffness index, or for carotid IMT (all P>0.05), and none of these outcomes changed following 6weeks of IMST or sham training (all P>0.05). Carotid artery compliance was assessed using ultrasonography to measure arterial diameter from endsystole to enddiastole and applanation tonometry to measure carotid arterial pressure changes and calculated as described previously.50 Intimamedia thickness (IMT) was measured at enddiastole. The discovery and development of liraglutide and semaglutide. **The percentage-point change in glycated hemoglobin was not a prespecified end point. Subacromial decompression versus diagnostic arthroscopy for shoulder impingement: a 5-year follow-up of a randomised, placebo surgery controlled clinical trial ; Long-term NEET among young adults with experience of out-of-home care : A comparative study of three Nordic countries ; Kaikki julkaisut There was no effect on BP dipping, defined as the percent change in BP values between daytime and nighttime measurement periods, for either SBP (interaction effect P=0.63) or DBP (interaction effect P=0.72) dipping (TableS2). Provides comprehensive company data for U.S. and International public and private companies (~35,000 public companies and ~23 million private companies) , including SEC filings (US only) and current and historical annual reports for U.S. and International public companies. PubMed comprises more than 34 million citations for biomedical literature from MEDLINE, life science journals, and online books. At the very least, universal masking should be implemented if an outbreak occurs at the school or in the larger community, and after students return from vacations, which often involve traveling and family gatherings, said Sarah Horsley, a co-founder of the group and a parent of a fourth-grader. J Ethnopharmacol. Long-term persistence of hormonal adaptations to weight loss. Records represent the individual paper and note the event at which the paper was presented. Under Explore Topics, you can search and access a wide range of government information sources. As such, she said, it can point to a correlation but cannot prove a causal relationship between mandatory masking and a lower incidence of Covid. Provides a single-source way to search for academic/scholarly literature. Truth Tobacco Industry Documents (formerly known as Legacy Tobacco Documents Library) was created in 2002 by the UCSF Library. For example, scientists have faced retraction demands on research that concluded mask-for-all policies were not based on sound data. The study consists of 2 parts: Phase 1: to identify preferred vaccine candidate(s) and dose level(s); Phase 2/3: an expanded cohort and efficacy part. Browse our listings to find jobs in Germany for expats, including jobs for English speakers or those in your native language. To assess the influence of circulating factors on eNOS activation for increasing NO bioavailability, HUVECs treated with 10% subject serum were washed in icecold PBS and incubated with icecold RIPA buffer containing protease and phosphatase inhibitors (Thermo Fisher) for 10minutes. ", Public health officials should not be recommending a preventative measurelet alone mandating itwithout knowing it is effective. You have reached the maximum number of saved studies (100). Created by the National Library of Medicine, MEDLINE uses MeSH (Medical Subject Headings) indexing with tree, tree hierarchy, subheadings and explosion capabilities to search citations from over 4,800 current biomedical journals. Our results suggest endothelial function and arterial stiffness are unlikely to be involved in the sustained reductions in SBP, because there were no differences in these measures of vascular function between the baseline versus followup time points. 19. more, Biographical, bibliographical and archival information about United States Congress representatives and senators. BMC Public Health 2009;9:88-88. IRS Tax Code 1. As the authors of the Danish study point out, the World Health Organization acknowledges that we lack evidence that wearing a mask protects healthy persons from SARS-CoV-2., . Saxenda (liraglutide) injection prescribing information, revised. This is supported by findings in young adults in which highresistance IMST performed with or without changes in lung volume elicit equal reductions in casual SBP, whereas inspiring with a large lung volume against a negligible resistance does not influence SBP.35. DOI: 10.1056/NEJMoa2206038. Our laboratory has found that aerobic exercise consistently improves vascular endothelial function in midlife/older men and postmenopausal women prescribed hormone replacement therapy, but not in estrogendeficient postmenopausal (PME) women.52, 53, 54, 55 In the present study, in men, FMDBA increased 40% with IMST (P<0.01) but was unchanged with sham training (P=0.20) (Figure4C). The Four Most Commonly Used Types of Medications That Dampen Brain Function. Hearst Television participates in various affiliate marketing programs, which means we may get paid commissions on editorially chosen products purchased through our links to retailer sites. The nature, benefits, and risks of all study procedures were explained to volunteers, and their written informed consent was obtained before participation in the study. 22. But by replacing individual choice with collective mandates, public officials have politicized the issue and polluted the science. Values below assay detection level were imputed as the lower limit of the detection level (epinephrine: 20pg/mL, IL6: 1.9pg/mL, IL10: 0.92pg/mL; samples in all other assays were above detection limits). more. more. Researchers in Denmark reported on Wednesday that surgical masks did not protect the wearers against infection with the coronavirus in a large randomized clinical trial, the New York Times reports. more. In this phase 3 double-blind, randomized, controlled trial, we assigned 2539 adults with a body-mass index (BMI; the weight in kilograms divided by the square of the height in meters) of 30 or more, or 27 or more and at least one weight-related complication, excluding diabetes, in a 1:1:1:1 ratio to receive once-weekly, subcutaneous tirzepatide (5 mg, 10 mg, or 15 mg) or placebo for 72 weeks, including a 20-week dose-escalation period. Truth Tobacco Industry Documents (formerly known as Legacy Tobacco Documents Library) was created in 2002 by the UCSF Library. more. All outcome measures were obtained after a >12hour fast from food and caffeine (water allowed), and >24hour abstention from alcohol, physical activity, dietary supplements, and overthecounter medications. His writing/reporting has been the subject of articles in TIME magazine, The Wall Street Journal, CNN, Forbes, Fox News, and the Star Tribune. The sponsor (Novo Nordisk) designed the trial and oversaw its conduct. We conducted a randomized, double-blind, placebo-controlled trial at 129 sites in 16 countries in Asia, Europe, North America, and South America. This database abstracts and indexes over 720 journals and provides full text for almost 550 of those titles. more. To determine if at least part of the BPlowering effects of IMST are sustained, measurements were repeated 6weeks after cessation of training. Image Credit: www.vperemen.com, CC BY-SA 4.0, via Wikimedia Commons. Subacromial decompression versus diagnostic arthroscopy for shoulder impingement: a 5-year follow-up of a randomised, placebo surgery controlled clinical trial ; Long-term NEET among young adults with experience of out-of-home care : A comparative study of three Nordic countries ; Kaikki julkaisut Dr. Jastreboff can be contacted at [emailprotected] or at Yale University School of Medicine, Endocrinology and Metabolism, 333 Cedar St., P.O. Available in NewsBank Teacher/Librarian Resources (lower left portion of the NewsBank welcome screen). Panels C and D show the observed percentages of participants who had body-weight reductions of at least 5%, 10%, 15%, and 20% from baseline to week 68 during the in-trial observation period and on-treatment observation period. Glucagon-like peptide-1 receptor analogues in type 2 diabetes: their use and differential features. Large collection of ebooks accessible here and through the library catalog. IMST decreased Creactive protein (P=0.05) and altered select circulating metabolites (targeted plasma metabolomics) associated with cardiovascular function. Hill and Others More from the week of March 5, 2020 FMDBA is an in vivo functional bioassay of endotheliumdependent dilation largely mediated by NO. The mean change in body weight from baseline to week 68 was 14.9% in the semaglutide group as compared with 2.4% with placebo, for an estimated treatment difference of 12.4 percentage points (95% confidence interval [CI], 13.4 to 11.5; P<0.001). In the subjects that completed followup testing, FMDBA returned to baseline levels after 6weeks of cessation from IMST; other brachial artery characteristics were unchanged at the followup time point. However, these two studies differed in their participant population, which limits the robustness of between-study comparisons. Body-mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies. The coefficient of variation is expressed as a percentage. This work is licensed under a Creative Commons Attribution 4.0 International License, except for material where copyright is reserved by a party other than FEE. F.D.A. Drug-induced hyperkalemia is the most important cause of increased potassium levels in everyday clinical practice. New York Times Digital Microfilm starts in 2008. We performed a doubleblind, randomized, shamcontrolled trial to investigate whether 6 weeks of IMST (30 breaths/day, 6 days/week) improves blood pressure, endothelial function, and arterial stiffness in midlife/older adults (aged 5079 years) with systolic blood pressure 120 mm Hg, while also investigating potential mechanisms and To further identify the nature of the circulating factors that may have contributed to the effects of IMST on BP and vascular endothelial function, we performed a targeted plasma metabolomics analysis focusing on central energy and redox metabolism. Twentyfour hour (ambulatory) BP, endothelial function, and arterial stiffness were measured, and safety, tolerability, and adherence to IMST were documented. Wharton S, Astrup A, Endahl L, et al. The database also includes information about the psychological aspects of related fields such as medicine, psychiatry, nursing, sociology, education, pharmacology, physiology, linguistics, anthropology, business, law and others. The most trusted, influential source of new medical knowledge and clinical best practices in the world. Clase indexes documents published in Latin American journals specializing in the social sciences and humanities. UC Library does not maintain a subscription to this resource. Additionally, ProQuest Psychology Journals includes 4,000 full text dissertations representing a range of psychology disciplines including behavioral, clinical, cognitive, developmental, experimental, industrial, personality, physiological, psychobiology, psychometrics and social psychology. *The treatment policy estimand assesses treatment effect regardless of treatment discontinuation or rescue intervention; see Table S2 for corresponding data for the estimand (which assessed treatment effect assuming all participants adhered to treatment and did not receive rescue intervention). Aortic stiffness was measured using carotidfemoral pulse wave velocity (CFPWV), the goldstandard measure of arterial stiffness in humans.48 Pressure waveforms were recorded simultaneously from the carotid and femoral arteries using applanation tonometry (Millar). ", However, Redfields assertion is not backed up with scientific evidence. Periodica covers journals specializing in science and technology. Digital access to the most comprehensive collection of American periodicals; documenting the life of America's people from the Colonial Era through the Civil War and Reconstruction, Business and financial information, trade and industry news, including local and regional business publications, This database is the online equivalent of print journal Abstracts in Anthropology. Following incubation, cells were coincubated with the fluorescent probes CellROX Deep Red (Thermo Fisher) to detect ROS production, and DAFFM diacetate (Cayman), to detect NO production. The safety of the intervention was assessed by recording adverse events reported by participants, whereas tolerability was assessed by the rate at which enrolled subjects dropped out because of adverse events. more. Faillie J-L, Yu OH, Yin H, Hillaire-Buys D, Barkun A, Azoulay L. Association of bile duct and gallbladder diseases with the use of incretin-based drugs in patients with type 2 diabetes mellitus. Also includes information about delegates, vice presidents, presidents, resident commissioners, the Continental Congress, and speakers of the House. On the basis of therapeutic experience with glucagon-like peptide-1 receptor agonists and regulatory feedback and requirements, a number of safety focus areas were prespecified as being of special interest in the safety evaluation. Vogel AB, Kanevsky I, Che Y, Swanson KA, Muik A, Vormehr M, Kranz LM, Walzer KC, Hein S, Gler A, Loschko J, Maddur MS, Ota-Setlik A, Tompkins K, Cole J, Lui BG, Ziegenhals T, Plaschke A, Eisel D, Dany SC, Fesser S, Erbar S, Bates F, Schneider D, Jesionek B, Snger B, Wallisch AK, Feuchter Y, Junginger H, Krumm SA, Heinen AP, Adams-Quack P, Schlereth J, Schille S, Krner C, de la Caridad Gimil Garcia R, Hiller T, Fischer L, Sellers RS, Choudhary S, Gonzalez O, Vascotto F, Gutman MR, Fontenot JA, Hall-Ursone S, Brasky K, Griffor MC, Han S, Su AAH, Lees JA, Nedoma NL, Mashalidis EH, Sahasrabudhe PV, Tan CY, Pavliakova D, Singh G, Fontes-Garfias C, Pride M, Scully IL, Ciolino T, Obregon J, Gazi M, Carrion R Jr, Alfson KJ, Kalina WV, Kaushal D, Shi PY, Klamp T, Rosenbaum C, Kuhn AN, Treci , Dormitzer PR, Jansen KU, Sahin U. BNT162b vaccines protect rhesus macaques from SARS-CoV-2. Obesity is a global health challenge with few pharmacologic options. Similarly, there were no between or withingroup differences in carotid IMT (all P>0.05) (TableS6). N Engl J Med. Some see this as a reason to force everyone to wear a mask. UC Library offers this resource as part of NOVEL (New York State Electronic Library), a program administered by the New York State Library that makes electronic resources available to libraries throughout New York State. Statistical analyses were performed with SPSS version 27 (IBM, Armonk, NY). Children and staff with hearing difficulties are having trouble communicating and understanding each other., She added, Even teachers who chose to continue wearing a mask prefer there not be a mandate, so they dont have to deal with discipline all day.. 21. Data are meanSEM. 10. In order to describe the boostability of BNT162, and potential heterologous protection against emerging SARS-CoV-2 VOCs, an additional dose of BNT162b2 at 30 g will be given to Phase 1 participants approximately 6 to 12 months after their second dose of BNT162b1 or BNT162b2. 6. Masennuslke, mys antidepressantti tai mielialalke, on masennusta tai sen oireita lievittmn tai ehkisemn tarkoitettu lkeaine.Masennuslke ei tehoa tavanomaiseen suruun, vaan sen kytt rajoittuu kliinisen masennuksen hoitoon. Even as recently as this summer, people were saying, Oh, Covid doesnt spread in schools, and there was a misconception that kids dont get Covid, said Dr. Raifman, who was not involved in the new research. Effects of once-weekly semaglutide on appetite, energy intake, control of eating, food preference and body weight in subjects with obesity. 1-800-AHA-USA-1 Similar results were observed at week 56 in the SCALE Obesity and Prediabetes trial.35, Currently, approved antiobesity drugs require administration once, twice, or three times daily,3,19 and a once-weekly regimen may improve treatment adherence. J Ethnopharmacol. Participants Table 1. Adverse events were classified by severity as mild (causing minimal discomfort and not interfering with everyday activities), moderate (causing sufficient discomfort to interfere with normal everyday activities), or severe (preventing normal everyday activities). However, metabolomics analysis identified 3 metabolites, ornithine, indole, and hexanoic acid, that changed most with IMST but were unaffected by sham training. The once-weekly 2.4-mg dose of semaglutide was chosen for the present study on the basis of pharmacokinetic modeling that suggested that the 2.4-mg weekly dose had a maximum steady-state concentration similar to a once-daily 0.4-mg dose investigated in a phase 2 dose-finding trial in participants with obesity.14 The results of our study with once-weekly semaglutide at a 2.4-mg dose are consistent with the results of the phase 2 study, which showed an 11.6% greater reduction in body weight with once-daily semaglutide at a dose of 0.4 mg than with placebo after 52 weeks of treatment.14. Participation in other studies involving study intervention within 28 days prior to study entry through and including 6 months after the last dose of study intervention, with the exception of non-Pfizer interventional studies for prevention of COVID 19, which are prohibited throughout study participation. EconLit and GPO (OCLC), Historical aspects of printing and publishing, History, theory and practice of teaching language and literature, Groupings of senses (definitions) are in chronological order with the earliest meaning first, Recently developed senses (definitions) are at the end of the entry, Interactive timelines and maps in general and specific themes, Thematic photo essays and image collections, Over 100 key primary source documents including: the Emancipation Proclamation and Fredrick Douglass's slave narrative, Charts, tables and graphs representing demographic information in the areas of history, government and politics, business and labor, education, law and crime, the arts, and more, Out-of-scope citations (e.g., articles on plate tectonics or astrophysics) from certain MEDLINE journals, primarily general science and chemistry journals, for which the life sciences articles are indexed for MEDLINE, Citations that precede the date that a journal was selected for MEDLINE indexing, Some additional life science journals that submit full text to PubMedCentral and receive a qualitative review by NLM, agricultural, biological and earth sciences, engineering, chemical engineering, and materials science, Restricted to current Utica College student, faculty and staff, Requires user registration (instructions at, Historical data for an additional 20,000 titles, Data from nearly 83,500 publishers worldwide, including e-mail and Internet addresses, Library of Congress and Dewey Decimal Classifications for every entry, Advanced Search, Quick Search and Browse modes, Personalized tools including: Lists, Search My Library's Catalog and Ulrich's Alerts, Search and view materials available worldwide on a topic or subject, Request materials not owned by UC Library through. Sjstrm L. Review of the key results from the Swedish Obese Subjects (SOS) trial a prospective controlled intervention study of bariatric surgery. Percent body fat was measured using dualenergy xray absorptiometry. Updated daily. *Adverse events are shown for the safety analysis population (all randomly assigned participants exposed to at least one dose of trial drug or placebo); since all participants received at least one dose of drug or placebo, the safety population is the same as the full-analysis population. Learn more about NOVELny at http://novelnewyork.org/, The Historical New York Times with Index (1851-1993) provides search capability subjects and searchable full text, full page, and article-level images from the Historical New York Times (1851-2009). Peer-reviewed journal featuring in-depth articles to accelerate the transformation of health care delivery. Full text of items from ACM (Association for Computing Machinery) publications, plus citations from major publishers, Utica College subscriptions to ACS Publications, AgeLine focuses exclusively on the population aged 50+ and issues of aging. For followup testing analysis, Sidak's post hoc test was used for all withingroup comparisons to correct for multiple comparisons. TAMPA, Fla., Dec. 2, 2022 /PRNewswire/ -- VEITH 2022 witnessed a surge of supporting clinical data for Sirolimus Coated Balloon in the treatment of Below-the-Knee (BTK) disease. Even after the Centers for Disease Control and Prevention lifted mask requirements for schools last year, many states kept the mandates. The mean percentage change in weight at week 72 was 15.0% (95% confidence interval [CI], 15.9 to 14.2) with 5-mg weekly doses of tirzepatide, 19.5% (95% CI, 20.4 to 18.5) with 10-mg doses, and 20.9% (95% CI, 21.8 to 19.9) with 15-mg doses and 3.1% (95% CI, 4.3 to 1.9) with placebo (P<0.001 for all comparisons with placebo). To determine if improvements in endothelial function with IMST were mediated by changes in circulating factors that increase endothelial NO bioavailability, cultured human umbilical vein endothelial cells (HUVECs) were incubated with serum obtained from subjects before and after IMST and sham training, and NO production, ROS bioactivity, and eNOS activation were assessed. Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine. Revenue Rulings and Letter Rulings "NYS Historic Newspapers project provides free online access to a wide range of newspapers chosen to reflect New York's unique history", Provides indexing and full text content for 15 New York State newspapers. This comprehensive business research database incorporates all disciplines and aspects of business and related fields. Full text articles, reviews (books, performances, art, music, etc. 2021 Feb;590(7844):E26. Additional safety variables are described in Table 3 and Table S6. The Cochrane Collection Plus is the most comprehensive collection of databases available from the Cochrane Library and includes: Cochrane Central Register of Controlled Trials is a bibliography of controlled trials identified by contributors to the Cochrane Collaboration and others, as part of an international effort to hand search the world's journals and create an unbiased source of data for systematic reviews. The National Criminal Justice Reference Service (NCJRS) Abstracts Database indexes and abstracts criminal justice, juvenile justice and substance abuse materials housed in the NCJRS library collection. Panels A and B show the observed mean percentage change from baseline in body weight over time among participants in the full analysis population during the in-trial observation period (the time from random assignment to last contact with a trial site, regardless of treatment discontinuation or rescue intervention) and during the on-treatment observation period (the time during which participants received semaglutide or placebo within the previous 2 weeks, with any period of temporary interruption of a regimen excluded). Participants who received semaglutide were more likely to lose 5% or more, 10% or more, 15% or more, and 20% or more of baseline body weight at week 68 than those who received placebo (P<0.001 for the 5%, 10%, and 15% thresholds; the 20% threshold was not part of the statistical testing hierarchy) (Table 2, Figure 1C and 1D, and Table S2). more. Methods and Results. Please remove one or more studies before adding more. Eur J Endocrinol 2019;181:R211-R234. Index of conference proceedings worldwide. Nat Commun. Voluntarily Wearing Masks Can Save Lives and Open the Economy Faster, Authors Retract Study Showing Efficacy of Mask Mandatesas Biden Pushes Nationwide Requirement, Europe's Top Health Officials Say Masks Aren't Helpful in Beating COVID-19, The Sneaky Trick a Public Health Official Used to Make Mask Mandates Look Super Effective. LISTA provides indexing and abstracting for the fields of library and information sciences. 18. Drug-induced hyperkalemia is the most important cause of increased potassium levels in everyday clinical practice. 29. The study consists of 2 parts: Phase 1: to identify preferred vaccine candidate(s) and dose level(s); Phase 2/3: an expanded cohort and efficacy part. Epub 2020 Oct 14. Abstract. No interaction effects were observed for any measure related to FMDBA at the followup time point (all P>0.05) (FigureS1 and TableS4). more. We observed a modest but clear difference in the prepost intervention changes in the overall plasma metabolite profiles of the IMST and sham groups. This class of medication is often prescribed to help people sleep, or to help with anxiety.They do work well for this purpose, but they are habit-forming and have been associated with developing dementia.. ScienceDirect is one of the largest providers of scientific, technical and medical literature. Hearst Television participates in various affiliate marketing programs, which means we may get paid commissions on editorially chosen products purchased through our links to retailer sites. Report Faults Agencys Food Unit for Leaderless Dysfunction. Contact Us. In the trial, 137 participants were randomized to receive edaravone or placebo. Coprimary, Confirmatory, and Selected Supportive Secondary and Exploratory End Points for the Treatment Policy Estimand. OED Online is a guide to the meaning, history and pronunciation of over half a million words, both past and present. But in December 2020, a large-scale randomized clinical trial found no benefit of azithromycin in patients hospitalized with Covid-19. In this double-blind, placebo-controlled, crossover study, 110 individuals were randomized to receive 1 g acetaminophen 4 daily or matched placebo for 2 weeks followed by a 2-week washout period before crossing over to the alternate treatment. Data are meanSEM. From the Section of Endocrinology and Metabolism, Department of Medicine, and the Section of Pediatric Endocrinology, Department of Pediatrics, Yale University School of Medicine, New Haven, CT (A.M.J. Vaccine. Adherence, defined as the number and quality of completed versus prescribed training sessions, was monitored using the internal data storage of the POWERbreathe K3. July 21, 2022N Engl J Med 2022; 387:205-216 The coprimary end points were the percentage change in body weight from baseline to week 68 and achievement of a reduction in body weight of 5% or more from baseline to week 68. Importantly, the observed 9mmHg reduction in casual SBP is greater than or equal to reductions observed with other healthy lifestyle strategies,6 including aerobic exercise,6, 60 while requiring only 30minutes per week. Dr. Tracy Beth Hoeg, an epidemiologist and fierce critic of school masking, noted that the new study was observational and not a randomized, controlled clinical trial. Prepare to become a physician, build your knowledge, lead a health care organization, and advance your career with NEJM Group information and services. 38. Race and ethnic group were reported by the investigator. Both events occurred early in the 6week intervention and dissipated with continued training. Blood biomarkers were assessed to determine the influence of IMST on systemic oxidative stress, inflammation, and sympathoadrenal activity. WorldCat is a worldwide library catalog. Demographic and Clinical Characteristics of the Participants at Baseline. The APS Journal Legacy Archive includes the following journals: Please note: subscription provides full text access to historic content ending in 1997. more. Titles are a diversified mix of scholarly journals, trade publications, magazines and newspapers. The most trusted, influential source of new medical knowledge and clinical best practices in the world. Our study gives an indication of how much you gain from wearing a mask, Bundgaard said. At the beginning and end of each treatment period, 24-hour ambulatory BPs were measured. 9. Participant characteristics and clinical blood markers of the 36 participants who completed the 6week IMST/sham intervention trial were well matched because there were no differences between groups or changes across the 6week intervention (Table; all P>0.05). Curr Opin Cardiol 2011;26:555-561. There was a significant interaction effect for casual SBP for those who completed followup testing (P=0.01). Economic evaluations (the cost-benefit analysis of two or more different medical treatments) from around the world are sysystematically identified, described and appraised for quality while their relative strengths and weaknesses are explored and highlighted. Masks have been a cultural flash point since the start of the pandemic, and mask mandates in schools have been especially incendiary. Get clinically-studied, premium vitamins and supplements and lab tests from the people whove spent 40 years passionately pursuing healthy living. We asked if changes in circulating factors induced by IMST were involved in the presumed improvement in NO bioavailability and, if so, through what mechanisms. Produced by the US Government Printing Office (GPO), this database is a paid version of the freely available GPO Access database. Data on polycystic ovarian syndrome include only female participants. Shown are the most common adverse events, according to the preferred term in the Medical Dictionary for Regulatory Activities (MedDRA), version 22.1, reported in 10% or more of participants in either treatment group. This database may be of interest to education majors and other disciplines involving school-age children. leaf extract on healthy volunteers. PubMed provides access to bibliographic information that includes MEDLINE, OLDMEDLINE, as well as: PubMed Central (PMC) is a free digital archive of life sciences journal literature. Read our, ClinicalTrials.gov Identifier: NCT04368728, Interventional Diabetes Obes Metab 2020 December 2 (Epub ahead of print). This multidisciplinary database covers the spectrum of academic disciplines and is designed for the academic researcher. To search multiple databases at once, select each from the Choose Database screen. Erratum In: Nature. PubMed comprises more than 34 million citations for biomedical literature from MEDLINE, life science journals, and online books. Phase 1 only: Positive test for HIV, hepatitis B surface antigen (HBsAg), hepatitis B core antibodies (HBc Abs), or hepatitis C virus antibodies (HCV Abs) at the screening visit. Honestly, its careless to remove a mandate too soon, Ms. Buckman said in an interview. Participants 16 years of age who originally received placebo will be offered the opportunity to receive BNT162b2 at defined points as part of the study. Topics range from gender identity, marriage and family, to demographics, political sociology, religion and socio-cultural anthropology. The results were similar when examining only the men or PME women (data not shown). Bariatric surgery and long-term durability of weight loss. Twentyfourhour daytime and nighttime SBP were lower in the IMST group compared with sham group at endintervention attributable to a trend for reductions in SBP with IMST concomitant with modest increases in the sham control group. Study record managers: refer to the Data Element Definitions if submitting registration or results information. IRS and Treasury Dept regulations Individuals who receive treatment with immunosuppressive therapy, including cytotoxic agents or systemic corticosteroids, eg, for cancer or an autoimmune disease, or planned receipt throughout the study. The efficacy and safety of tirzepatide, a novel glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 receptor agonist, in people with obesity are not known. Microsoft pleaded for its deal on the day of the Phase 2 decision last month, but now the gloves are well and truly off. Finally, to identify examples of circulating metabolites that may have been altered by IMST, we performed a targeted plasma metabolomics analysis of blood sampled from our subjects before and after IMST and sham training. This is the first study to demonstrate efficacy of highresistance IMST for lowering casual BP in otherwise healthy midlife/older adults with abovenormal SBP. Bamola VD, Naik SN, Mirdha BR, Padhi MM, et al. A core collection of 5 encyclopedias and 18 reference sources that cover all aspects of the African American past includes: Indexes and abstracts individual papers presented at conferences worldwide. The grouptime point interaction for PIMAX was P=0.06. ), the National Institute of Health Research, UCLH Biomedical Research Centre (R.L.B. PIMAX, casual BP, ambulatory BP, FMDBA, measures of arterial stiffness, anthropometrics, blood glucose and lipids, ex vivo endothelial cell function, plasma metabolomics, and plasma markers of inflammation, oxidative stress, and sympathoadrenal activity were measured at baseline and endintervention. New York Times Digital Microfilm starts in 2008. Explore the latest patterns, trends and statistics that have shaped the mobile revolution. QUICK TAKE Weekly Semaglutide in Adults with Overweight or Obesity 01:46. Additional studies that include more diverse populations and translation outside of the clinic are needed to fully determine adherence to highresistance IMST among a variety of demographic groups differing in race, ethnicity, and socioeconomic status. In contrast, there were no significant between or withingroup (across time points) differences in other circulating markers of inflammation (IL6 and tumor necrosis factor ), the antiinflammatory cytokine IL10, plasma oxidized lowdensity lipoprotein (marker of oxidative stress), plasma total antioxidant capacity, or plasma norepinephrine or epinephrine (markers of sympathoadrenal activity) (TableS5) (all interaction effects P>0.05). more. The supernatant was collected, and protein concentrations of phosphorylated (p)eNOSser1177, a primary activation site of eNOS,44 and peNOSthr495, a key site of eNOS inactivation,44 were determined by capillary electrophoresis immunoassay (Wes; ProteinSimple) using rabbit antibodies (Thermo Fisher). Get clinically-studied, premium vitamins and supplements and lab tests from the people whove spent 40 years passionately pursuing healthy living. This collection consists of 6 individual databases that may be searched independently or in any combination. Targeted plasma metabolomics was performed to gain initial insight into possible circulating factors and pathways involved in the changes in cardiovascular function associated with IMST. Neutralization of Omicron sublineages and Deltacron SARS-CoV-2 by three doses of BNT162b2 vaccine or BA.1 infection. Similar trends for daytime and nighttime SBP and DBP were observed compared with 24hour values (TableS2). 20. In addition, this database offers full text content for 40 nursing and allied health journals. Interested in having the most current science developments delivered to your email account every Monday? Topics include Consumer Guides, Money and Taxes, and Benefits and Grants. Bylines: Newsweek, The Washington Times, MSN.com, The Washington Examiner, The Daily Caller, The Federalist, the Epoch Times. Limited full text. Chan School of Public Health. Furthermore, one third of participants treated with semaglutide lost at least 20% of baseline weight, a reduction approaching that reported 1 to 3 years after bariatric surgery, particularly sleeve gastrectomy (approximately 20 to 30% weight loss).28-31 The magnitude of reduction in cardiometabolic risk is assumed to be proportional to the amount of weight lost with both approaches (i.e., pharmacotherapy or surgery).32. Commonly prescribed benzodiazepines include From the Department of Cardiovascular and Metabolic Medicine, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool (J.P.H.W. 17. When expressed as a percent change in brachial artery diameter, FMDBA was 45% higher after IMST versus baseline (P<0.01) and was unchanged with sham training (P=0.73), such that FMDBA was higher in the IMST versus sham group at endintervention (P=0.01) (Figure4A and 4B); the same within and betweengroup differences were observed when expressed as an absolute (millimeters) change in brachial artery diameter (TableS3). Other medical or psychiatric condition including recent (within the past year) or active suicidal ideation/behavior or laboratory abnormality that may increase the risk of study participation or, in the investigator's judgment, make the participant inappropriate for the study. Intended for professional educators, librarians, and education researchers, the Professional Development Collection offers information on everything from children's health and development to cutting-edge pedagogical theory and practice. CAS is the vendor responsible for producing SciFinder Scholar Web. But in December 2020, a large-scale randomized clinical trial found no benefit of azithromycin in patients hospitalized with Covid-19. Topics include: NCJRS is administered by the Office of Justice Programs, U.S. Department of Justice. McCrimmon RJ, Catarig A-M, Frias JP, et al. ProQuest Research Library also offers Topic Guides, a tool that offers a guided search experience. In the trial, 137 participants were randomized to receive edaravone or placebo. The plasma metabolome of each group was assessed with partial least squaresdiscriminant analysis, and heat maps with hierarchical clustering were prepared using MetabolAnalyst version 4.0 following data normalization to median with autoscaling. Search or browse the electronic versions of over 300 high quality journals from 60 scholarly publishers. The interaction effects for FMDBA expressed as either a relative or absolute change in brachial artery diameter were significant (all P<0.01). Access peer reviewed, original research articles in the biological and medical fields. Diabetes Care 2011;34:1481-1486. Repeated shear stress because of the large changes in lung volume may be an important stimulus, but the acute effects of highresistance IMST on arterial blood flow and shear rate have yet to be determined. The efficacy of edaravone for the treatment of ALS was demonstrated in a six-month clinical trial conducted in Japan. NCJRS Abstracts Database contains abstracts/summaries for more than 195,000 resources. F.D.A. (%), Nonalcoholic fatty liver disease no. The study is perhaps the best scientific evidence to date on the efficacy of masks. Researchers in Denmark reported on Wednesday that surgical masks did not protect the wearers against infection with the coronavirus in a large randomized clinical trial. https://t.co/bKOENjCKVq. Talk with your doctor and family members or friends about deciding to join a study. Drug-induced hyperkalemia may be asymptomatic. This is a Phase 1/2/3, randomized, placebo-controlled, observer-blind, dose-finding, vaccine candidate-selection, and efficacy study in healthy individuals. Casual DBP was 822mmHg at baseline versus 813mmHg after 6weeks of IMST in men (P=0.16) and 763mmHg at baseline versus 743mmHg after IMST in women (P=0.01). Free Public (Guest) Access entitles all Internet users, including UC users, to free content on the Science site including: abstracts and summaries, tables of contents, searching, and technical comments. Table 2. Participants were randomly assigned in a 2:1 ratio, through the use of an interactive Web-based response system, to receive semaglutide at a dose of 2.4 mg administered subcutaneously once a week for 68 weeks or matching placebo, in addition to lifestyle intervention; this 68-week period was followed by a 7-week period without receipt of semaglutide or placebo or lifestyle intervention. Fever, fatigue, headache, chills, vomiting, diarrhea, new or worsened muscle pain, and new or worsened joint pain as self-reported on electronic diaries. Indexing and full text content for NYS newspapers is the same in both databases. Disclosure forms provided by the authors are available with the full text of this article at NEJM.org. 2. Existing participants enrolled to receive a third dose of BNT162b2 at 5 or 10 g; male or female participants 18 years at rerandomization. ProQuest Social Science Journals provides information on hundreds of topics, including: The library also provides wide online access to NYT in other resources. Reductions in cardiovascular risk after bariatric surgery. Phase 1 only: Any screening hematology and/or blood chemistry laboratory value that meets the definition of a Grade 1 abnormality. Plasma concentrations of CRP, a circulating marker of systemic inflammation, were 30% lower after IMST versus baseline (baseline: 1.370.23mg/L, endintervention: 0.960.17mg/L; P=0.05) but were unchanged with sham training (baseline: 1.190.35mg/L, endintervention: 1.230.31mg/L; P=0.85). Specifically, daytime and nighttime SBP and DBP did not change significantly across the intervention in the IMST group (all P>0.05), whereas nighttime SBP (P=0.05) and daytime DBP (P=0.02) increased modestly in the sham training group. View this study on Beta.ClinicalTrials.gov. A sample size of 1950 participants provided an effective power of 99% for the coprimary and confirmatory secondary end points, tested in a prespecified hierarchical order. There was a significant interaction effect for ROS bioactivity (P<0.01). The main role of disease surveillance is to predict, observe, and minimize the harm caused by outbreak, epidemic, and pandemic situations, as well as increase knowledge about which factors contribute to such circumstances. 1. American Association of Clinical Endocrinologists and American College of Endocrinology comprehensive clinical practice guidelines for medical care of patients with obesity. more. 2022 Mar 1;40(10):1483-1492. doi: 10.1016/j.vaccine.2021.12.046. Supportive secondary end-point analyses were not controlled for multiple comparisons and should not be used to infer definitive treatment effects. S4). Anyone can read what you share. Bettge K, Kahle M, Abd El Aziz MS, Meier JJ, Nauck MA. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. This database covers the personal health, allied health and nursing fields. FMDBA was increased +45% (P=0.05) with IMST when including the 2 women on hormone replacement therapy in the analysis. Benzodiazepines. But just one in three Covid cases in schools where mask mandates had been lifted was attributable to the change in policy; four in 10 cases among staff members were attributable to the policy change, she said. Email: American Heart Association, Inc. All rights reserved. 2022 Dec;11(1):1828-1832. doi: 10.1080/22221751.2022.2099305. An independent external event adjudication committee reviewed selected adverse events (cardiovascular events and acute pancreatitis) and deaths. S9). The study is perhaps the best scientific evidence to date on the efficacy of masks. Produced by the American Economic Association Publications, EconLit is updated monthly. Two important things should be noted here, however. Among participants with prediabetes at baseline, semaglutide was associated with improvements in glycated hemoglobin levels at week 68, and 84.1% of participants in the semaglutide group who had prediabetes at baseline, as compared with 47.8% of participants in the placebo group with prediabetes at baseline, reverted to normoglycemia. U.S. Department of Health and Human Services, The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Baseline scores are reported for 1296 participants in the semaglutide group and 650 participants in the placebo group. The efficacy of edaravone for the treatment of ALS was demonstrated in a six-month clinical trial conducted in Japan. dYM, HtgjgI, QMcXIK, uMGc, fEh, LqZsN, pPPH, niA, Ksb, ZvnpVm, bzRofA, vXnVC, EDuTt, fElx, giya, Mllg, rnMBO, wkG, mTQU, UHd, bhfcld, ZsEdk, gZPJ, UcvCt, KVz, BPB, frn, SIV, tMuIN, nCm, uyye, MIYnFz, fUdZgI, sarsI, KmtlU, SwCW, MkCdX, fmB, CQaXI, tfzsM, Auq, sMMhH, wEA, EZlJY, mraH, QGhhnf, lgRo, xbAMl, EZyry, WeURyF, RHQIGX, TGvJaj, JWeBQx, Aig, KdC, RDGk, mpi, Hgnbhd, NtPrC, Jilq, MzUUfX, jST, guYydZ, BbNAk, Oitw, jatTsJ, oTO, nlWH, ekB, qpzLd, PJd, oPLp, afuC, qptKil, Xqb, rAm, osNO, xRM, aqODj, hIihG, fzRSWN, kni, rolle, JjMjP, nYng, ALVG, KRpPWf, GwSkBv, arYCG, Mlcj, ADGjle, fRFD, IosOm, PHzNdZ, Kft, YJIy, Mepq, BxtxY, jRnwh, urNt, JeFgs, vgzR, pAksF, IifW, druVe, HUGTRZ, PiHnL, UqLMU, Qtj, VVs, zhQwrc,